Epididymo-orchitis caused by intravesically instillatedbacillus Calmette-Guerin: genetically proven using a multiplexpolymerase chain reaction method.
Links Epididymo-orchitis caused by intravesically instillated bacillus Calmette-Guerin: genetically proven using a multiplex polymerase chain reaction method. Harada H, Seki M, Shinojima H, Miura M, Hirano T, Togashi MInt J Urol. 2006 Feb;13(2):183-5. Links Epididymo-orchitis caused by intravesically instillated bacillus Calmette-Guerin: genetically proven using a multiplex polymerase chain reaction method. Harada H, Seki M, Shinojima H, Miura M, Hirano T, Togashi M. Department of Urology, Sapporo City General Hospital, Sapporo, Japan. hiroshi.harada@doc.city.sapporo.jp The intravesical instillation of bacillus Calmette-Guerin (BCG) is a standard therapy for superficial bladder carcinoma. Tuberculosis-like inflammation in the genitourinary tract is a serious complication of BCG. It can occur after a long interval from the cessation of the intravesical BCG therapy. If inflammation occurs, it is necessary to test whether the BCG strain has caused it or another mycobacterium species has. However, there has never been a report that proves BCG causes the inflammation, because BCG is difficult to differentiate from other strains of Mycobacterium bovis and other members of the Mycobacterium tuberculosis complex by conventional tests, including regular polymerase chain reaction (PCR). We first present a case of epididymo-orchitis, which developed 31 months after the cessation of BCG therapy, detected using a multiplex PCR method as having been caused by BCG. Our report illustrates the efficacy of this method to detect the responsible microbe that is thought to be transmitted from the instillated BCG strain. PMID: 16563148 [PubMed - indexed for MEDLINE] Related Links Epididymo-orchitis developing as a late manifestation of intravesical bacillus Calmette-Guerin therapy and masquerading as a primary testicular malignancy: a report of 2 cases. [J Urol. 1992] PMID: 1433567 Late occurrence of bilateral tuberculous-like epididymo-orchitis after intravesical bacille Calmette-Guerin therapy for superficial bladder carcinoma. [Urology. 2005] PMID: 15667898 Preoperative diagnosis of bilateral tuberculous epididymo-orchitis following intravesical Bacillus Calmette-Guerin therapy for superficial bladder carcinoma. [Australas Radiol. 2002] PMID: 12060159 Epididymo-orchitis following intravesical bacillus Calmette-Guerin therapy. [Ann Pharmacother. 2000] PMID: 10772435 Granulomatous hepatitis caused by Bacillus Calmette-Guerin (BCG) infection after BCG bladder instillation. [Gut. 1996] PMID: 8707098 See all Related Articles... Display Summary Brief Abstract AbstractPlus Citation MEDLINE XML UI List LinkOut ASN.1 Related Articles Cited Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Gene (GeneRIF) Links Genome Links Project Links GENSAT Links GEO Profile Links HomoloGene Links Nucleotide Links Nucleotide (RefSeq) Links OMIA Links OMIM (calculated) Links OMIM (cited) Links BioAssay Links Compound Links Compound via MeSH Substance Links Substance via MeSH PMC Links Cited in PMC PopSet Links Probe Links Protein Links Protein (RefSeq) Links SNP Links Structure Links Taxonomy via GenBank UniGene Links UniSTS Links Show 5 10 20 50 100 200 500 Sort by Pub Date First Author Last Author Journal Send to Text File Printer Clipboard E-mail Order .
Department of Urology, Sapporo City General Hospital, Sapporo, Japan. hiroshi.harada@doc.city.sapporo.jp
The intravesical instillation of bacillus Calmette-Guerin (BCG) is a standard therapy for superficial bladder carcinoma. Tuberculosis-like inflammation in the genitourinary tract is a serious complication of BCG. It can occur after a long interval from the cessation of the intravesical BCG therapy. If inflammation occurs, it is necessary to test whether the BCG strain has caused it or another mycobacterium species has. However, there has never been a report that proves BCG causes the inflammation, because BCG is difficult to differentiate from other strains of Mycobacterium bovis and other members of the Mycobacterium tuberculosis complex by conventional tests, including regular polymerase chain reaction (PCR). We first present a case of epididymo-orchitis, which developed 31 months after the cessation of BCG therapy, detected using a multiplex PCR method as having been caused by BCG. Our report illustrates the efficacy of this method to detect the responsible microbe that is thought to be transmitted from the instillated BCG strain.
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