[Two patients with mumps]
Links [Two patients with mumps] [Article in Dutch] van Brummelen SE, de Vries E, Schneeberger PM, van Binnendijk RS, Lestrade P, Wever PCNed Tijdschr Geneeskd. 2006 Aug 5;150(31):1732-5. Links [Two patients with mumps] [Article in Dutch] van Brummelen SE, de Vries E, Schneeberger PM, van Binnendijk RS, Lestrade P, Wever PC. Jeroen Bosch Ziekenhuis, Postbus 90.153, 5200 ME's-Hertogenbosch. Two patients, men aged 17 and 19 years respectively, were admitted with parotitis epidemica and orchitis caused by mumps. The second patient also had meningitis. PCR analysis revealed that, in both cases, the causative agentwas a mumps virus that was genetically related to a wild-type virus responsible for an outbreak in Singapore. This viral strain was also responsible for a mumps outbreak at Hotel School The Hague in September 2004. Both patients were not fully vaccinated. Both patients were from regions in which clustering of patients with clinical signs of mumps has been seen. Interestingly, a number of patients with confirmed mumps had been fully vaccinated. Possible explanations for the increase in mumps cases include low vaccination and immunity levels, primary and secondary vaccine failure and the emergence of genetically disparate mumps viruses. PMID: 16924947 [PubMed - indexed for MEDLINE] Related Links Hemagglutinin-neuraminidase sequence and phylogenetic analyses of mumps virus isolates from a vaccinated population in Singapore. [J Med Virol. 2003] PMID: 12696120 Phylogenetic analysis of clinical mumps virus isolates from vaccinated and non-vaccinated patients with mumps during an outbreak, Switzerland 1998-2000. [J Med Virol. 2004] PMID: 15042654 Analysis of mumps vaccine failure by means of avidity testing for mumps virus-specific immunoglobulin G. [Clin Diagn Lab Immunol. 1998] PMID: 9801337 Differentiation of vaccine and wild mumps viruses using the polymerase chain reaction and dideoxynucleotide sequencing. [J Gen Virol. 1990] PMID: 2324711 Differentiation of the mumps vaccine strains from the wild viruses by the nucleotide sequences of the P gene. [Vaccine. 1990] PMID: 2087876 See all Related Articles... Display Summary Brief Abstract AbstractPlus Citation MEDLINE XML UI List LinkOut ASN.1 Related Articles Cited Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Gene (GeneRIF) Links Genome Links Project Links GENSAT Links GEO Profile Links HomoloGene Links Nucleotide Links Nucleotide (RefSeq) Links OMIA Links OMIM (calculated) Links OMIM (cited) Links BioAssay Links Compound Links Compound via MeSH Substance Links Substance via MeSH PMC Links Cited in PMC PopSet Links Probe Links Protein Links Protein (RefSeq) Links SNP Links Structure Links Taxonomy via GenBank UniGene Links UniSTS Links Show 5 10 20 50 100 200 500 Sort by Pub Date First Author Last Author Journal Send to Text File Printer Clipboard E-mail Order .
Jeroen Bosch Ziekenhuis, Postbus 90.153, 5200 ME's-Hertogenbosch.
Two patients, men aged 17 and 19 years respectively, were admitted with parotitis epidemica and orchitis caused by mumps. The second patient also had meningitis. PCR analysis revealed that, in both cases, the causative agentwas a mumps virus that was genetically related to a wild-type virus responsible for an outbreak in Singapore. This viral strain was also responsible for a mumps outbreak at Hotel School The Hague in September 2004. Both patients were not fully vaccinated. Both patients were from regions in which clustering of patients with clinical signs of mumps has been seen. Interestingly, a number of patients with confirmed mumps had been fully vaccinated. Possible explanations for the increase in mumps cases include low vaccination and immunity levels, primary and secondary vaccine failure and the emergence of genetically disparate mumps viruses.
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