[Evaluation of brucellosis patients in Trakya University Hospital]
Aydoslu B, Celik AD, Kuloglu F, Tansel O, Akata F, Tugrul MMikrobiyol Bul. 2006 Jul;40(3):257-63. [Evaluation of brucellosis patients in Trakya University Hospital] [Article in Turkish] Aydoslu B, Celik AD, Kuloglu F, Tansel O, Akata F, Tugrul M. Trakya Universitesi Tip Fakultesi, Klinik Bakteriyoloji ve infeksiyon Hastaliklari Anabilim Dali, Edirne. Human brucellosis is an endemo-epidemic disease in the Trakya Region of Turkey. The aim of this retrospective study was to evaluate the clinical, laboratory findings, therapeutic features, and prognosis of the 47 patients (49% were female, age range: 17-76 years, mean age: 45 years) with human brucellosis followed up in Trakya University Hospital between 2001-2005. The patients were categorized as acute (64%), subacute (28%) and chronic (9%) brucellosis. Complications were detected in 51% of the patients and spondylodiscitis was the most common (30%) complication. Twenty-seven percent of patients with spondylodiscitis were classified as acute, 46% were subacute, and 27% were chronic brucellosis. Other complications were sacroileitis (9%), arthritis (4%), meningitis (4%), endocarditis (2%), and orchitis (2%). Positive blood cultures were detected in 80% and 54% of acute and subacute cases, respectively, however, blood cultures were all negative in the chronic cases. Overall positive blood cultures were observed in 68% of cases. Fifty-one percent of the patients were treated with doxycycline+streptomycin, and 40% with doxycycline+rifampicin. Two patients with meningitis were treated with doxycycline+rifampicin+ceftriaxone, and one patient with endocarditis was treated with doxycycline+rifampicin+cotrimoxazole combinations. Relapse was observed in two (4%) of the patients. Since serious complications were observed in half of the brucellosis patients, combination therapies were prolonged. Complete evaluation of patients with human brucellosis requires investigation of osteoartricular complications and modification of the duration of therapy according to the existing complication. PMID: 17001856 [PubMed - in process] Related Links Brucellar epididymo-orchitis in Saudi Arabia: a retrospective study of 26 cases and review of the literature. [BJU Int. 2001] PMID: 11446850 [Retrospective evaluation of brucellosis cases inhabiting in Mus province] [Mikrobiyol Bul. 2006] PMID: 17001861 Ofloxacin plus rifampicin versus doxycycline plus rifampicin in the treatment of brucellosis: a randomized clinical trial [ISRCTN11871179]. [BMC Infect Dis. 2004] PMID: 15214959 [Comparison of the diagnostic value of blood and bone marrow cultures in brucellosis] [Mikrobiyol Bul. 2006] PMID: 17001849 Human brucellosis in Kuwait: a prospective study of 400 cases. [Q J Med. 1988] PMID: 3051080 See all Related Articles... Display Summary Brief Abstract AbstractPlus Citation MEDLINE XML UI List LinkOut ASN.1 Related Articles Cited Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Gene (GeneRIF) Links Genome Links Project Links GENSAT Links GEO Profile Links HomoloGene Links Nucleotide Links Nucleotide (RefSeq) Links OMIA Links OMIM (calculated) Links OMIM (cited) Links BioAssay Links Compound Links Compound via MeSH Substance Links Substance via MeSH PMC Links Cited in PMC PopSet Links Probe Links Protein Links Protein (RefSeq) Links SNP Links Structure Links Taxonomy via GenBank UniGene Links UniSTS Links Show 5 10 20 50 100 200 500 Sort by Pub Date First Author Last Author Journal Send to Text File Printer Clipboard E-mail Order .
Trakya Universitesi Tip Fakultesi, Klinik Bakteriyoloji ve infeksiyon Hastaliklari Anabilim Dali, Edirne.
Human brucellosis is an endemo-epidemic disease in the Trakya Region of Turkey. The aim of this retrospective study was to evaluate the clinical, laboratory findings, therapeutic features, and prognosis of the 47 patients (49% were female, age range: 17-76 years, mean age: 45 years) with human brucellosis followed up in Trakya University Hospital between 2001-2005. The patients were categorized as acute (64%), subacute (28%) and chronic (9%) brucellosis. Complications were detected in 51% of the patients and spondylodiscitis was the most common (30%) complication. Twenty-seven percent of patients with spondylodiscitis were classified as acute, 46% were subacute, and 27% were chronic brucellosis. Other complications were sacroileitis (9%), arthritis (4%), meningitis (4%), endocarditis (2%), and orchitis (2%). Positive blood cultures were detected in 80% and 54% of acute and subacute cases, respectively, however, blood cultures were all negative in the chronic cases. Overall positive blood cultures were observed in 68% of cases. Fifty-one percent of the patients were treated with doxycycline+streptomycin, and 40% with doxycycline+rifampicin. Two patients with meningitis were treated with doxycycline+rifampicin+ceftriaxone, and one patient with endocarditis was treated with doxycycline+rifampicin+cotrimoxazole combinations. Relapse was observed in two (4%) of the patients. Since serious complications were observed in half of the brucellosis patients, combination therapies were prolonged. Complete evaluation of patients with human brucellosis requires investigation of osteoartricular complications and modification of the duration of therapy according to the existing complication.
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